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References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

Central Government Pharmacy (CG). shorescopy.des-AuslandGlosstra Drugs (United Kingdom). glosstra.comCgDPharmacy.Haque Pharmacy.Jaw Drug (India). jaw.comJaw Pharmacy.Haque.Central Government. Tadalafil 20mg Tablets. [Revised in November 2009] [Revised in September] [Accessed on November 08th, 2023]://[Revised in September] [Accessed on November 08th, 2023]

Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.

Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.

You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.

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Common symptoms of hormonal changes include nausea, vomiting, headache, and dizziness. Symptoms of hormonal changes may include irregular heartbeat, dizziness, or a slight increase in menstrual blood flow. chest pain, indigestion, and muscle pain. Back pain and pain in legs and back are other common symptoms of hormonal changes. alpha-blockers are used to treat high blood pressure; depression. Treatment with alpha-blockers may help relieve symptoms of heart failure, such as shortness of breath, blood pressure irregularities, or blood vessel problems. chest pain, indigestion, and muscle pain.oilsong antibacterium, which is an anti-inflammatory medication used to treat back pain or muscle pain associated with inflammation of the feet and lower legs. oilsongredirectsbuildingsisterhood

Headache, back pain, and muscle pain are some of the common side effects that may occur. If these side effects persist or become bothersome, speak to your doctor first.

Read the Risks and Side Effects of Tadalafil

Tadalafil is not suitable for everyone. You and your doctor have a lot to do to get the group of medicines Tadalafil you are taking to be suitable for you. Here are some other ways to get Tadalafil you are taking to look for some benefits. Some ways to make Tadalafil more effective include:

• Taking tadalafil with a higher dosage as high as possible has been proven to increase your overall effectiveness. This may be true of other medicines you are taking, too. This is called high-dose Tadalafil therapy. • Taking tadalafil with a low dosage of tadalafil as low as possible has been proven to increase your overall effectiveness. This is called low-dose Tadalafil therapy. Some ways to make Tadalafil more effective include: • Taking tadalafil with a low dosage of tadalafil as low as possible has been proven to increase your overall effectiveness. This medicine is not recommended for use in children as its effects can be cause for concern. • Taking tadalafil with a high dosage of tadalafil as high as possible has been proven to increase your overall effectiveness. Some ways to make Tadalafil more effective includes: • Taking tadalafil with a high dosage of tadalafil as high as possible has been proven to increase your overall effectiveness.

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Explore generic alternativesExplore alternative formulationsExplore branded alternativesComparing Cialis and Generic Tadalafil

Judgingblind autopsy of a man who suffered from erectile dysfunction (ED) is critical in determining the safety of these medications. Both Cialis and generic tadalafil have been proven effective, and they are both FDA-approved. However, they have differences in the active ingredients, dosage, and other factors. Understanding the safety profile of these medications and the factors that can impact them is essential for patients and healthcare providers to make informed decisions about their use.

This review aims to highlight how these generic alternatives can be safer and more effective than brand name medications. The information provided in this article is based on information received from leading medical sources and does not take the place of your healthcare provider or pharmacist.

Brand name	Generic alternatives	Factors that impact safety
Cialis	Tadalafil	Generic alternative

Table: Generic alternatives for tadalafil (20 mg)

Tadalafil (20 mg) is used to treat erectile dysfunction (ED), which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. Tadalafil (20 mg) is available by prescription only. This medication is also used to treat benign prostatic hyperplasia (BPH), also known as an enlarged prostate. It works by relaxing the muscles in the prostate and bladder and improving urine flow. However, the generic alternative tadalafil is only available as an oral tablet and is not approved by the FDA for this use. You should always check the manufacturer's product information or consult your doctor before using this medication.

RiteAid® (StrileAid®)Tadalafil is an injectable medication used to treat erectile dysfunction (ED) and is available in tablets. It works by helping the blood vessels in your penis fill with blood and produce an erection. Tadalafil is a prescription-only version of Cialis® that you should only use as directed by your doctor. This medication can cause side effects such as headache, flushing, and back pain. If you are taking tadalafil to treat ED, you should follow the instructions on the prescription label carefully.

Cialis® (Tadalafil)Cialis® is a once-daily, once-weekly, and once-daily tablet taken on an as-needed basis. It is available in 2.5mg, 5mg, 10mg, and 20mg tablets. The recommended starting dose is 10mg, taken approximately 1 hour before sexual activity. You should take Cialis for approximately 2 hours before sexual activity. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take your dose at the same time as the regular dose.

Do not take Cialis or generic tadalafil more often than directed. It is not recommended to exceed the recommended dose.

Cialis and tadalafil are both available in the US, EU, and Canada. In Europe, the generic version of tadalafil is available as the brand-name Cialis®. You can also purchase generic tadalafil without a prescription from CVS, Walmart, and Rite Aid. Generic tadalafil is available in the US, Canada, and Europe.

How Tadalafil Works

Before we explain how Tadalafil helps manage ED, we need to explain how erections occur naturally. When you become aroused, your body releases a substance called nitric oxide (NO). In turn, levels of a chemical known as cyclic guanosine monophosphate (cGMP) increase in your body, relaxing the muscles on the sides of your penis so blood can flow into the organ and trigger a stiff erection.

While all this is happening, your body also compresses the veins that take blood away from the penis, so that the blood remains in place and you can maintain that erection. Eventually, the PDE5 enzyme in your body gets to work, and it processes the cGMP. When that happens, your erection dissipates, and the penis becomes flaccid once again.

If you have ED, regardless of the underlying cause, this natural process is somehow interrupted. That makes it more difficult for you to get or maintain an erection that’s sufficient for intercourse. And that’s where Tadalafil, a PDE5 inhibitor, can help. By blocking this enzyme in your body, you’ll have an easier time getting an erection and holding on to it until sex is complete.

As a PDE5 inhibitor, you’ll typically take Tadalafil 1–2 hours before sex. That means you would get flaccid for up to four hours after taking Tadalafil.

If you take Tadalafil after a high-fat meal, you’ll get an extended-releasestatus (OTO) of this substance called nitric oxide (NO). That means you’re also capable of holding onto that same amount of blood if you have ED.

The same substance also gets to work with an and. This substance naturally wears off within four hours after taking Tadalafil. That four-hour window can be extended if you maximized it by taking Tadalafil 15 minutes before sex.

How Tadalafil Works with Erectile Dysfunction

If you’re struggling with ED, there are ways to manage it. Viagra, another PDE5 inhibitor, offers the same management — and can also help with ED. And, because Viagra targets the PDE5 enzyme, it also lowers cGMP. That’s good news because cGMP also decreases. That doesn’t make it any less effective, however. And that can help with ED.

If you experience ED with other medications, such as alprostadil or nitrates, you may need to change your dosage. That may be more than enough to achieve an erection, but it’s still not a guarantee of effectiveness. And that can make it more difficult to get an erection again, so you’ll still need to maintain an erection for sex.

If you experience ED with another type of medication, such as penile implants, you may need to increase your dosage. That may be enough to make it more effective, but it still isn’t a guarantee of safety.

If you experience ED with another type of medication, such as penile implants, you may need to decrease your dosage.

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